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What is the best pain medication for chronic pain? Acetaminophen. Acetaminophen is usually recommended as a first line treatment for mild to moderate pain, such as from a skin injury, headache or musculoskeletal condition. Acetaminophen is often prescribed to help manage osteoarthritis and back pain.

What is the best over the counter anti inflammatory? Nonsteroidal anti - inflammatory drugs (NSAIDs) are drugs that help reduce inflammation, which often helps to relieve pain. In other words, they're anti - inflammatory drugs. Some of the more common OTC NSAIDs are: aspirin. ibuprofen (Advil, Motrin, Midol) naproxen (Aleve, Naprosyn)

What is the best treatment for joint pain? For moderate-to-severe joint pain with swelling, an over-the-counter or prescription nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen (Advil, Motrin), or naproxen sodium (Aleve), can provide relief.

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